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Cetylpyridinium Chloride (CPC)

Cetylpyridinium Chloride (CPC) or 1-Hexadecylpyridinium Chloride is a quaternary ammonium compound that demonstrates varying degrees of activity against bacteria. CPC is widely used in over-the-counter products including mouthwash, throat lozenges, nasal sprays and antiseptic (first aid) creams and lotions.  It is also used as an active pharmaceutical ingredient and an excipient in pharmaceutical products. CPC meets requirements for monographs of the US, European and Japanese Pharmacopoeia.

Effectiveness of CPC against bacteria

Compared to other antimicrobials, CPC is especially effective against Gram-positive bacteria.

Effectiveness of CPC as an oral antiseptic

When Cetylpyridinium Chloride (CPC) used as an oral health care antimicrobial product, CPC has shown reductions in bacterial oral plaque which contributes to hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP). Comprehensive oral care procedures can address bacterial colonization of the oral cavity, dental plaque, and aspiration with the assistance of CPC.

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