Fine Chemicals/Life Sciences Active Ingredients, Contract Manufacturing, Intermediates & Process Aids


The protection of various functionalities with acetate and tosylates, (and similar groups such as mesylates, benzoates, tritylates, etc), is well known. In fact, treatment of amines and alcohols with acetic anhydride in the presence of a base, such as pyridine, has been a well established procedure since the turn of the 20th century.

DMAP is accepted as a good catalyst for acylation and has applications in many Pharmaceuticals that require this type of reaction. For instance, in many antivirals such as acyclovir, famcyclovir etc. It also has uses in many other reactions such as Michael reactions, alkylation, amination, phosphorylation and many API’s today use DMAP in the synthesis.  Today, DMAP remains of significant commercial use and is a prime tool in most organic chemists arsenal for process optimization and discovery. DMAP is used by innovator and generic API manufacturers in all regions of the world.

Vertellus offers two grades of N,N-Dimethyl-4-aminopyridine, the standard flaked DMAP and the Easy-Flo® DMAP grade. Easy-Flo® DMAP grade is a pelletized product that improves product handling by improving flowability, reducing dust and helping prevent product compaction.