Piperidine in Pharmaceuticals

Piperidine is an organic heterocyclic amine that occurs naturally and is prepared synthetically through the hydrogenation of pyridine over a metal catalyst.  Piperidine and its derivatives are common building blocks in pharmaceuticals, fine chemicals, and specialty chemicals. Piperidine can also act as a solvent and as a base and has great utility as a reagent in synthetic chemistry. 


Metabolic Intermediate

Piperidine is a base and a solvent in pharmaceutical manufacturing.  Piperidine is useful as a reagent in solid phase peptide synthesis, acting to prevent unwanted side reactions in the peptide sequence and promoting amino acid coupling by proton scavenging.  Peptide-based therapies are highly specific and recognized for their safety, efficacy, and patient tolerance.  They find broad pharmaceutical applications including in metabolic diseases and oncology.


Typical Properties

Acid Value
Hydroxyl Value
Saponification Value
Iodine Value
Melt Point (°C)
Specific Gravity

Values shown in the above table are typical properties.

Application Highlights


Used in metabolism drugs

Artifical Food Dye

Used to provide color to otherwise colorless food

Additional Resources

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